NR2B相关论文
背景与目的:神经炎症反应在帕金森病的发病和疾病进展中发挥重要作用。我们的前期研究发现帕金森小鼠脑组织中存在小胶质细胞的激......
目的：观察电针、药线点灸、电针合药线点灸对带状疱疹后遗神经痛模型大鼠的镇痛效应及作用机制。方法：将50只大鼠随机等分为5组，其中1......
目的:观察电针心包经穴对大脑中动脉闭塞（middle cerebral artery occlusion,MCAO）模型大鼠的神经功能缺损、脑梗死体积及梗死脑组织......
目的 探讨氧化锂-匹罗卡品(li-pilo)致癫痫大鼠认知障碍与年龄的相关性研究及其可能的致病机制.方法 新生SD大鼠在出生后第21天经......
目前,中国的人口老龄化趋势愈发明显,而随着我国医疗技术的不断发展与进步,很多老年患者选择接受手术治疗疾病。研究显示,年龄因素......
目的：观察艾灸天枢(ST25)和上巨虚穴(ST37)对IBS内脏痛敏大鼠脊髓NR1、NR2B和PKCε的调节作用,揭示艾灸对IBS内脏高敏感的脊髓NMDA......
目的 NR2B基因是多种神经系统疾病的致病基因，其精确表达与学习记忆、空间定向能力、维持神经系统正常功能关系密切，通过研究人与wis......
Upregulation of CCL2/CCR2 in the Nucleus Accumbens contributes to pain hypersensitivity and depressi
Objective: Chronic pain patients are usually accompanied with depression,anxiety,and anhedonia.Recent evidence showed th......
Xanthotoxol ameliorates the ischemia/reperfusion-induced impairment of long-term potentiation induct
Aim: Cerebral ischemia can impair the induction of activity-dependent longterm potentiation (LTP) in the hippocampus.Her......
The role of synaptic-and extrasynaptic NMDA receptors on induction of long-term plasticity in mice h
Long-term Plasticity is an important hypothesis for learning and memory.As disclosed from many experimental data,an acti......
大量证据显示前扣带皮层(ACC)在痛觉信息处理中具有关键性作用.在ACC,兴奋性突触传递主要由谷氨酸介导,前脑过度表达NMDA受体NR2B......
目的 观察慢性酒精暴露后Wistar大鼠不同戒断时间点纹状体N—甲基—D—天冬氨酸(N-methyl-D-aspartate,NMDA)受体2B亚基(NMDA rece......
Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing
Aim: In this study we investigated anti-nociceptive effects of oxymatrine through regulation of NR2B-containing NMDA rec......
Effect of NR2B antagonist against Aβ25-35 induced acute synaptic plasticity disruption in rat hippoc
Aim: Amyloid beta (Aβ)-induced synaptic dysfunction is thought to be an important event in early stage of Alzheimers di......
目的 探讨钩藤碱对甲基苯丙胺诱导的斑马鱼条件性位置偏爱(CPP)的影响.方法天然偏爱测定(d1～3)合格的斑马鱼腹腔注射甲基苯丙胺(40 ......
Glycine binding sites of presynaptic NR2B-containing NMDA autoreceptors may tonically regulate gluta
Johnson and Ascher first demonstrated that,in the vertebrate central nervous system (CNS),exogenously applied glycine po......
目的：观察在缺血缺氧条件下，星形胶质细胞NMDA受体2B亚型(NR2B)和谷氨酸转运体EAAT2mRNA的表达，并观察钩藤碱对缺血-缺氧后星形胶质细......
目的：本研究通过RT-PCR检测miR-21在骨癌痛大鼠脊髓水平的表达,以及观察过表达miR-21对疼痛行为、靶基因蛋白及脊髓神经细胞活化的......
IL-1β Promotes Seizure Susceptibility after Febrile Sei-zures through Activation of the NR2B Phospho
OBJECTIVE The aim of this study was to investigate whether the activation of the NR2B phosphrylation participate in the ......
The up-regulation of BDNF mRNA on focal cerebral ischemia-reperfusion injury in rats with polysaccha
AIM To study the effect of polysaccharides from Opuntia Milpa Alta (MAPs) on mRNA expression of brain-derived neurotroph......
Modulating balance of synaptic and extrasynaptic NMDA receptors(NMDARs)shows priority over nonselect
OBJECTIVE Alzheimer disease(AD)patients suffer a disturbance in the balance between synaptic NMDARs(NR2A,mediating the p......
背景：氯胺酮快速抗抑郁作用及其机制研究是当前科学界研究的热点之一。氯氨酮作为离子型谷氨酸NMDA受体拮抗剂,具有快速抗抑郁作用......
The stability of NR2B In the nucleus accumbens controls behavioral and synaptic adaptations to chron
Aim: The nucleus accumbens (NAc) is closely correlated with psychiatric disorder.It has been demonstrated that the gluta......
Background: Microwave radiation could change the activity, numbers, gene and protein expression of NMDAR 2B (NR2B), whic......
目的观察右美托咪定对幼鼠海马组织NR2B表达及学习记忆能力的影响。方法将80只购自河南实验动物中心的无特定病原体(SPF)级新生SD......
目的研究5-氮杂-2′-脱氧胞苷(5-Aza-CdR)对小鼠在跳台实验中的学习和记忆能力及其海马组织中NR2B 1472位点的酪氨酸磷酸化(p-Y147......
目的疼痛是组织损伤所引起的一种不愉快的主观感觉和情绪体验。长期慢性疼痛的病人通常伴有抑郁、易怒、兴趣缺失、动机行为下降等......
目的 NR2B基因的表达与调控与空间定向障碍、前庭疾病易感性等密切相关,通过生物信息学技术对NR2B基因启动子区域多态性位点(singl......
目的:探讨加兰他敏对急性酒精中毒大鼠海马神经元N-甲基-D-天冬氨酸(NMDA)·R2B的影响。方法:将60只大鼠分为对照组、酒精组及加兰......
目的:研究早期离体培养的人胚胎海马神经干细胞(NSCs)中NMDA受体亚单位NR2A和NR2B的表达。方法:取胎龄8～12周人胚脑海马,进行NSCs分......
目的 在小鼠骨癌痛模型上观察鞘内注射N-甲基-D-天冬氨酸受体2B亚基(NR2B)拮抗剂艾芬地尔的镇痛效果.方法 将含2×105个纤维肉瘤细......
目的 探讨鞘内注射钙/钙调蛋白依赖性蛋白激酶Ⅱ( CaMKII)抑制剂KN93对骨癌痛小鼠脊髓NR2B蛋白表达的影响及机制.方法 SPF级雄性C3......
目的探讨鞘内重复注射驱动蛋白17(Kinesin superfamily 17，KIF17)反义寡核苷酸对骨癌痛小鼠脊髓水平mLin10(mammalian orthologue o......
目的观察慢性酒精暴露后Wistar大鼠不同戒断时间点纹状体NMDA受体2B亚基(NMDA receptor 2B subunit，NR2B)表达的变化。方法72只雄性......
目的 探讨创伤性脑损伤(TBI)后小鼠海马区N-甲基-D-天冬氨酸(NMDA)受体2B亚基(NR2B)及其磷酸化(pNR2B)的表达变化和意义.方法 健康......
目的 探讨芬太尼、咪达唑仑复合麻醉对大鼠认知功能及海马NR1、NR2B表达的影响.方法 雄性Wistar大鼠随机分为3组,即对照组、复合麻......
突触后致密物( PSD)是位于中枢神经系统突触后膜的特殊结构，它是由一系列细胞骨架蛋白与受体、激酶等传递突触信号相关分子结合形成......
目的 研究5-氮杂-2′-脱氧胞苷(5-Aza-CdR)对小鼠在跳台实验中的学习和记忆能力及其海马组织中NR2B 1472位点的酪氨酸磷酸化(p-Y14......
Objective:To observe the influence of moxibustion on learning and memory ability in the rats with vascular dementia(VD)a......
随着社会的老龄化,2型糖尿病(type 2 diabetes mellitus,T2DM)已成为我国不容忽视的一个健康问题.认知功能障碍是糖尿病的慢性并发......
目的:本实验应用艾芬地尔对脑缺血再灌注损伤(ischemia reperfusion injury,IRI)大鼠进行治疗,探究其对NR2B亚基表达的影响及脑保......
